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England, J

Definition of CIN The definition of CIN varies widely and refers to the development of acute renal impairment following the intravascular administration of radiocontrast dye in the absence of other identifiable causes of renal failure

This mirrors the escalation approach used with semaglutide, which makes sense given that Novo Nordisk designed both compounds

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acidinducible gene-I and melanoma differentiationassociated gene 5

Importantly, many of the early trials excluded patients with comorbidities or any degree of renal insufficiency, which should be kept in mind as enrolment and indications for these drugs increase