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They noted brain increases in the oxidative stress-related marker malondialdehyde and decreases in the protective enzyme SOD

Santos PW, Machado ART, De Grandis R, Ribeiro DL, Tuttis K, Morselli M, et al

The cytoplasmic enrichment could reflect several non-exclusive possibilities: protection of reactive cysteines from oxidation or unwanted disulfide formation, regulation of protein-protein interactions, or modulation of enzyme activities in response to cytoplasmic acetyl-CoA levels