Therapeutic hypothermia-induced infarction significantly increased myocardial mitophagy, reducing cellular stress, apoptosis, inflammation, and fibrosis
Disclosures: Khurram Jamil: Mallinckrodt Pharmaceuticals: Employee, Galectin Therapeutics: Stock - publicly traded company, Galectin Therapeutics: Employee, Naim Alkhouri: Madrigal: Grant/Research Support, Madrigal: Speaking and Teaching, Novo Nordisk: Consulting, Novo Nordisk: Grant/Research Support, Gilead: Grant/Research Support, Corcept: Grant/Research Support, Boehringer Ingelheim: Grant/Research Support, Echosens: Speaking and Teaching, Perspectum: Consultant, Cima: Consultant, Fibronostics: Consultant, 89Bio: Grant/Research Support, Inventiva: Grant/Research Support, Merck: Grant/Research Support, Pfizer: Grant/Research Support, Ipsen: Speaking and Teaching, Intercept: Speaking and Teaching, Madrigal: Consulting, Research Funding, Novo Nordisk: Consulting, Research Funding, Inventiva: Research Funding, Boehringer Ingelheim: Consulting, Research Funding, Corcept: Research Funding, Ipsen: Consulting, Research Funding, Gliead: Consulting, Research Funding, Speaking, Perspectum: Consulting, Research Funding, Cima: Advisor, 89Bio: Consulting, Research Funding, Akero: Grant/Research Support, Mitchell Shiffman: Bio89: Grant/Research Support, CymaBay: Advisor, CymaBay: Grant/Research Support, Durect: Grant/Research Support, Galectin: Grant/Research Support, Genentech: Grant/Research Support, Genentech: Speaking and Teaching, Gilead: Grant/Research Support, Gilead: Advisor, Gilead: Speaking and Teaching, HepQuant: Grant/Research Support, HepQuant: Advisor, Hamni: Grant/Research Support, High Tide: Grant/Research Support, Interept: Grant/Research Support, Interecept: Speaking and Teaching, Intercept: Advisor, Intra-Sana: Advisor, Intra-Sana: Speaking and Teaching, Ipsen: Advisor, Ipsen: Grant/Research Support, Ipsen: Speaking and Teaching, Madrigal: Grant/Research Support, Madrigal: Speaking and Teaching, Mirum: Grant/Research Support, Pliant: Grant/Research Support, Salix: Grant/Research Support, Salix: Advisor, Viking: Grant/Research Support, Hesham Elgouhari: Nothing to Disclose, Eric Lawitz: Nothing to Disclose, Edward Mena: Nothing to Disclose, Raj Vuppalanchi: Nothing to Disclose, CHIRAG PATEL: Nothing to Disclose, Seth Zuckerman: Galectin Therapeutics: Employee, Pol Boudes: Galectin Therapeutics, Inc.: Employee 2136 A MULTI-SCALE COMPUTATIONAL MODEL OF THE HEPATIC CIRCULATION APPLIED TO PREDICT THE PORTAL PRESSURE AFTER TRANSJUGULAR INTRAHEPATIC PORTOSYSTEMIC SHUNT (TIPS) Yang Ling 1 Jiaqi Gu 2 Yi Xiang 3 Jitao Wang 3 Deqiang Ma 4 He Zhu 5 Tianyu Liu 6 Chunlong Li 7 Qi Zhang 3 Jiahao Han 3 Deping Ding 4 Wei Wang 5 Qianlong Li 6 Haoguang Wan 7 Tianqi Wang 8 Xiaolong Qi 3 , 1 Zhongda Hospital, Southeast University, 2 School of Medicine, Southeast University, 3 Zhongda Hospital, 4 Taihe Hospital, 5 The Sixth People's Hospital of Shenyang, 6 Suining Central Hospital, 7 The Six Affiliated Hospital of Nantong U, 8 Gongli Hospital Medical Technology Background: Transjugular intrahepatic portosystemic shunt (TIPS) is a widely used surgery for patients with portal hypertension
Cell Chem Biol 30(9):1090-1103.e7 Yoshioka H et al (2022) Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1)
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The same finding was obtained when the experiments were repeated with extracts of rat brain and heart as well as rabbit bladder tissue
