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In a phase 2 dose-finding trial, once-weekly Cagrilintide produced clinically meaningful weight loss about 10.8% at the 4.5 mg dose over 26 weeks with gastrointestinal effects the most common adverse events [1]

Therefore, even though the upper limit of the laboratory reference range has changed, the lower end of the reference range remains the same

doi: 10.1182/blood-2017-10-809293 43 BuschLMougiakakosDBttner-HeroldMMllerMJVolmerDABachCet al

Comparison of three diuretic treatment strategies for patients with acute decompensated heart failure