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Hum Psychopharmacology 22: 67-73

N-acetylation protects the peptide from enzymatic breakdown at its leading end, while amidation stabilizes the trailing end

(PubMed) Carr AC, Block G, Lykkesfeldt J

Researchers administered intravenous DSIP to insomnia patients over several days and conducted polysomnographic sleep studies to objectively measure sleep architecture changes including time to sleep onset, total sleep time, and sleep stage distribution