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Although a 2004 Cochrane review found insufficient evidence to support the use of these antivirals alone, 15 two recent placebo-controlled trials demonstrated full recovery in a higher percentage of patients treated with an antiviral drug in combination with prednisolone than with prednisolone alone (100 percent versus 91 percent and 95 percent versus 90 percent)

Gut 72 , 10931100 (2022)

It accomplishes this by using protecting groups around the amino acids of GHRH typically susceptible to enzymatic degradation, thus increasing the half-life