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TFR1, which binds and internalizes ferritin, exhibits altered expression in cancer cells

Upon examination of mitochondria by electron microscopy, both the 5FU-treated and control groups exhibited comparable mitochondrial structures

This is very important, especially in light of the ADA position [37], which recognizes that the personalization of anti-diabetic therapyrather than a one-size-fits-all treatmentis necessary to achieve successful glycemic targets