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Interestingly, aging attenuates the phagocytosis of peritoneal macrophages but not bone marrow-derived macrophages and suggests that the high susceptibility to NTM infection in the elderly population may be associated with aging-related dysfunction of tissue-resident alveolar macrophages ( HDTs modulate macrophage functions for MAC infection The host susceptibility factors of MAC infection have allowed a deeper understanding of the hostpathogen interactions in MAC, confirming the importance of host immunological function in MAC infection

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Furthermore, the decrease in neurotransmitters, including glutamate and dopamine, may result in decreased pyramidal neuron firing (Vitrac et al., 2014)

Similarly, it was suggested in another study that the co-administration of the antioxidant vitamin C with chemotherapy drugs such as cisplatin and doxorubicin could decrease ROS necessary for medication-mediated cell death in more than 10% of subjects (37)