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CABI Agric Biosci 4:27

Appl Sci 12:4084 Singer M (2014) The role of mitochondrial dysfunction in sepsis-induced multi-organ failure

Notably, heatmap showing the expressions of significantly expressed genes from the pathways of interest was generated by the R package ggplot2 using the metric FPKM, and was colored by the z-score that was computed from the average FPKM of samples in each stage by subtracting the value of the average FPKM in the four stages then dividing by the standard deviation

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GSH-Px is a crucial enzyme that plays a key role in protecting cells against oxidative damage by catalyzing the reduction of hydrogen peroxide and organic hydroperoxides using glutathione as a cofactor, protecting cell membrane structure and keeping membrane function integrity