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Patients and methods This retrospective, single-arm case series included 62 consecutive patients with symptomatic knee OA (KOA) and MRI-confirmed femoral or tibial subchondral BMLs

The widely-expressed transmembrane glycoprotein CD38 has both receptor and enzymatic functions, and serves as a link between inflammation and metabolism

Plan to return in one week for results and further evaluation if needed

Ask a clinician for serum B12 and a complete blood count

Athletes involved in sports that put a lot of pressure on the knees, such as long-distance running, may be at higher risk for osteoarthritis of the knee