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Acyl-CoA synthetase long-chain family member 4 (ACSL4) is involved in ferroptosis mechanism

[DOI] [PMC free article] [PubMed] [Google Scholar] 144.Trabanelli S., Ocadlikova D., Ciciarello M., Salvestrini V., Lecciso M., Jandus C., Metz R., Evangelisti C., Laury-Kleintop L., Romero P., et al

Research indicates that microglia act as biological sensors to regulate neuronal activity, and any changes in DAn, such as -syn aggregates, apoptotic cells, and neurotransmitter release, may trigger a response (Salter and Stevens, 2017)

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Conversely, after APAP injection in hepatic specific PGC-1 overexpressing mice, the high expression of primary ROS scavengers is not able to counteract the hepatic oxidative stress induced by APAP, due to the collapse of GSH reservoir caused by the lowered Gcl-c expression and by the massive utilization of GSH for NAPQI detoxification performed by Glutathione S-Transferases