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10.2332/allergolint.09-RAI-0125 11

The recommended dose of Pemetrexed for maintenance treatment of non-squamous NSCLC : in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m2 as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle until disease progression or unacceptable toxicity after four cycles of platinum-based first-line chemotherapy

We may also ask about any allergies or previous reactions to IV treatments

There is some thought that since Pycnogenol can improve endothelial function and reduce catecholamine excess, it might actually mitigate some physical side effects of stimulants (like if a stimulant raises heart rate, Pycnogenol might blunt that increase a bit by improving vascular function)

Ltd., Japan)