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By interpreting the perturbations occurring upon drug treatment at the metabolic pathways level, a more comprehensive understanding of the impact of drugs on the complexity of cells metabolic networks can be achieved

However, when the drug is taken in an overdose, the Uridine diphosphate-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) in the human liver that participate in APAP detoxification become saturated, and a considerable proportion of this drug is activated by human CYPs (primarily CYP2E1)

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Zhang W, Li R, Lu D et al (2025) Phospholipids and peroxisomes in ferroptosis: the therapeutic target of acupuncture regulating vascular cognitive impairment and dementia

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