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Similarly, denosumab modified radiographic progression and decreased structural damage in erosive hand OA in a placebo-controlled, double-blind, randomized phase 2a clinical trial by acting as RANKL inhibitor by preventing the binding of RANKL to its receptor RANK on osteoclast precursors and reducing the expression of NFATc1 and TRAP

however, its activity is positively correlated with the advanced invasion and metastasis phenotypes of breast cancer in vivo [18]

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What about safety, contraindications, and special populations This is where FDA labeling really matters