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Health practitioners should base their guidance on the best available evidence and take into account the individual needs and health status of their patients

While both drugs act on the JAK/STAT signaling pathway, ritlecitinib results in inhibition of a narrower cytokine spectrum due to its selectivity for JAK3, whereas baricitinib inhibits both JAK1 and JAK2

This chronic, systemic depletion leaves the immune system profoundly exhausted and unable to properly regulate its own inflammatory responses, directly contributing to the persistent systemic inflammation, profound physical fatigue, and heightened susceptibility to secondary infections that characterize the daily Long COVID experience

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