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To gain greater insight into the specific sequence-structure-function relationships among GUS proteins, particularly those belonging to the L1 class, we generated a sequence similarity network (SSN), which groups protein sequences into clusters and facilitates the analysis of functional relationships within protein families 24

Furthermore, additional mechanisms are reported to regulate GLS, such as RNA-binding protein regulation of alternative splicing [68,69] or protein degradation through the ubiquitin ligase complex APC/C-Cdh1 during cell cycle progression [70]

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(3) Organotoxicity: ALT/AST (liver), creatinine/urea (kidney), histopathological staining [186]

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