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It highlights the pathological processes through which gut microbiota dysbiosis exacerbates systemic inflammation and lung injury via multiple pathways, including alterations in metabolites (such as bile acids and tryptophan), inhibition of the anti-inflammatory pathway mediated by the vagus nerve, and activation of TLR signals in the lungs by circulating toxins

Sokolov AV, Chekanov AV, Kostevich VA, Aksenov DV, Vasilyev VB, Panasenko OM

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This dysregulation is especially problematic in the case of critical illness when a lack of Se might worsen NTIS because thyroid hormones are not regulated adequately to meet the needs of metabolism [52]

F., Haiser, H