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Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an autosomal dominant inherited disease that originates from germ-line mutations in the fumarate hydratase (FH) gene

In systemic lupus erythematosus (SLE), which is characterized by chronic activation of self-reactive lymphocytes and myeloid cells, untargeted lipidomics using LC/MS and GC/MS has revealed altered serum concentrations of choline, ACh, phosphocholine, and specific species of PC, lysoPC, and sphingomyelin (192194)

31,32 Considering this information, the natural history of cNF is poorly understood for multiple reasons: patients can develop many cNFs throughout life, cNF burden varies greatly among NF1 patients and the precise sequence and nature of all cNF-initiating events is unknown

18 found that 11.3% of patients with 1000 IU/L ALT or AST (defined as acute liver injury by the authors) had DILI

FAP-CAR-Ms and FAP-CAR-ZETA-Ms derived from bone marrow inhibited activation of FAP-positive hepatic stellate cells in vivo , promoting extracellular matrix degradation via downregulation of Col1a1 and Acta2 and upregulation of MMP-9 and MMP-13 (89)