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At mRNA levels, 4-HNE inhibited collagen II expression but induced MMP13 expression [78]

By binding to cardiolipin, Elamipretide stabilizes mitochondrial cristae, improves membrane integrity, and enhances oxidative phosphorylation (Minkler et al., 2015)

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The study demonstrated that MOTS-c levels in the blood of centenarians, individuals who have survived to 100 years and older, were significantly higher than in age-matched individuals with shorter lifespans, and resembled levels seen in much younger adults [2]