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Each subunits active site is buried deep within the protein structure, and is only accessible from the surface via channels lined with hydrophobic amino acids

Along those lines, mouse studies have shown that rapamycin treatment protects against high-fat diet-induced obesity in mice

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Since selenium supplementation in the forms of sodium selenite and SeM was well documented to induce the expressions of seleno-GPxs through their metabolic assimilation into bioavailable selenium (hydrogen selenide), the initial studies focused on exploring selenium supplementation as a strategy to achieve protection against radiation-induced toxicity [38, 66]

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