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The absence of mucin, a highly glycosylated polymeric protein in the mucous layer, makes an animal vulnerable to intestinal inflammation, which leads to the development of spontaneous colitis and confers a predisposition to the development of colorectal cancers (Fig

In this regard, zDHHCs can be targeted by the drug discovery efforts

Eur Heart J 41:40574070

doi: 10.1016/j.fertnstert.2008.02.096 37 MatsumotoHNasuKNishidaMItoHBingSMiyakawaI

In many neurological diseases, comprising both neurodegenerative and neurodevelopmental disorders, alterations in DNA methylation occur at specific genomic regions, including gene promoters, enhancers and CpG islands (25)