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Description

Br J Cancer (2008) 99(3):46472

Embodiment A69 (a further embodiment of Embodiment A1) provides a compound that is (2R)-2-(5-Fluoro-2-methoxypyridin-4-yl)-1-[(2S)-7-methyl-6-(pyrimidin-2-yl)-3,4-dihydro-1H-spiro[1,8-naphthyridine-2,3-pyrrolidin]-1-yl]propan-1-one

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In addition to these pharmacokinetic advantages, SDKP maintains selected bioactivities associated with cytoskeletal modulation and tissue remodeling in vitro, making it a useful probe for dissecting TB-500related pathways