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Summary Keywords fragment screening, trypanosomatid infection, trypanothione reductase, rational drug discovery, protein crystallography Citation Fiorillo A, Colotti G, Exertier C, Liuzzi A, Seghetti F, Salerno A, Caciolla J and Ilari A (2022) Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design

Subjects with more severe hepatic impairment (i.e., higher ChildPugh scores) might have increases in apixaban exposure due to more significantly reduced CYP-mediated metabolism, despite the presence of other elimination pathways

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Nabeshima, K

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