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Changes in ECG parameters such as ischemia, conduction delays, arrythmia indicates signs of cardiac hypertrophy, collagen deposition, myocardial infarction, and structural remodeling of the heart 28,29

Similarly, hypoxic-TME and subsequent HIF1 and VEGF expression play a role in the polarization of M1 to M2 macrophage phenotype and differentiation of TAMs from immature myeloid cells [64,65]

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doi: 10.1016/j.intimp.2023.110802 56 HamadF.MubofuE