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The duration depends on individual factors such as metabolism and lifestyle

PeerJ, 7: e7497 Perez A S C, Challis J K, Ji X, Giesy J P, Brinkmann M (2022)

There are many reasons why the body requires vitamin B12

Guez, Sophie, et al

Other targets that are affected by alcohol include cannabinoid, opioid and dopamine receptors, although it is unclear whether alcohol affects these directly or if they are affected by downstream consequences of the GABA/NMDA effects