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AGEs exert their pathogenic effects primarily through binding to the receptor for RAGE, a transmembrane receptor expressed on endothelial cells, macrophages, and other immune cells, thereby triggering pro-inflammatory and pro-fibrotic signaling cascades (109)

However, iron overload can constitute a scenario prone to damage to the organism, including oxidative stress, deterioration of cellular and subcellular membranes, and thus leading to cell death

Bonomini M, Sirolli V, Settefrati N, Dottori S, Di Liberato L, Arduini A

[DOI] [PMC free article] [PubMed] [Google Scholar] 221.Kocatrk P.A., Akbostanci M.C., Tan F., Kavas G.O

P4170) were used to segregate leucocyte subsets as part of a single multiplexed panel