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10.1073/pnas.90.8.3569 97 GolubnitschajaO.DebaldM.YeghiazaryanK.KuhnW.PetaM.CostigliolaV.et al (2016)

These compounds signal fibroblasts and endothelial cells to rebuild connective tissue and increase blood vessel formation, leading to faster wound healing and stronger tissue integrity

Senolytic agents include natural compounds such as quercetin 13 or fisetin 14 , -galactosidase-activated nanoparticles and prodrugs 15,16,17 or compounds that target different vulnerabilities of senescent cells, such as HSP90 inhibitors 18 , cardiac glycosides 19,20 or NMT inhibitors 21

The peak fiber CSA in treated mice was maintained at approximately 2000 m, a value comparable to that in WT mice (~2500 m) and substantially greater than the reduced range (5001500 m) observed in untreated ALS mice (Fig

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