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Hendrix J, Nijs J, Ickmans K, Godderis L, Ghosh M, Polli A

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Deletion of HIF-2 in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice

Muscle weakness, severe fatigue, or unusual cramping also warrant medical evaluation

TB-500 is frequently dosed in larger loading amounts up front and lower maintenance amounts later, so saving the setup avoids re-deriving the units each phase