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After reviewing literature and conducting a two-round Delphi survey with 42 experts, a consensus emerged that emphasizes prioritizing clinical symptoms in diagnosis, with serum B12 as a screening marker supported by methylmalonic acid or homocysteine levels for additional confirmation

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Extending to a CRC patient-derived xenograft (PDX) model adjacent to iWAT, IDO1/TDO2 inhibition also sensitized tumours to the ferroptosis inducer IKE (Fig