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Modern pharmacological studies have reported that tetramethylpyrazine (TMP), an active metabolite in Ligusticum chuanxiong , possesses various physiological functions, including antioxidant capabilities, anti-inflammatory actions, anti-apoptotic characteristics, the ability to regulate autophagy, vasodilatory functions, modulation of angiogenesis, inhibition of mitochondrial damage, safeguarding of endothelial cells, and mitigation of vascular smooth muscle cell proliferation and migration, and also offers neuroprotective benefits ( in vivo experiments using a mouse model of focal ischemic stroke (IS), TMP upregulates the expression of monocyte chemoattractant protein-induced protein one to inhibit neuroinflammatory responses, while protecting the integrity of the BBB ( Ligusticum chuanxiong

Firstly, motor neurological signs (Buchanan and Heinrichs, 1989) recorded at baseline were associated with initial or baseline level of the ratio of Xant to Gr, indicating the higher a patients initial or baseline ratio of Xan to Gr, the greater his or her motor neurological signs was before initiating treatment with antipsychotic medications

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