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Increased activity of these phase II detoxification enzymes enhances the bodys ability to manage oxidative stress and inflammatory mediators that contribute to metabolic syndrome (Ngo and Duennwald, 2022)

Reference ranges vary between laboratories, so results should be interpreted according to local thresholds

Liposomal systems often have limited drug loading capacity, also may lead to leakage or abnormal release rate, affecting treatment outcomes ( in vivo accumulation, which may increase the risk of pulmonary fibrosis, chronic toxicity, or other adverse outcomes

Cis-aconityl group Cis -aconityl group, an amide derivative of maleic acid, has also been employed as an acid-cleavable linkage for designing pH-responsive polymer-drug conjugates and drug carriers

see Supplemental Table S1 )