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Patients typically receive injections once or twice weekly for the first two weeks, followed by monthly maintenance doses, making the treatment cost-effective for those requiring consistent B12 supplementation

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The number of patients completing their follow-up measurements between November and April, which is the period of low sun exposure in the northern latitudes [22], was indeed markedly higher in the Optimum 2.0 group compared to the Optimum 1.0 group, especially at 3 years of follow-up (77% vs 50%)