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In the following sections, we delineate the key considerations that drive the chemical design of protein-based therapeutics and describe the various design strategies that have led to ~350 approved drug products (Supplementary Tables S1S3)

Although chlorpheniramine maleate and cetirizine hydrochloride have tolerable side effects, they induce severe side effects on chronic use such as hepatitis and cholestatic jaundice

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Methods 9 , 671675

G-jZ: Investigation, Writing original draft