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For a molecule to act as an antioxidant, it must fulfil the two criteria

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Pollutants also act as potent environmental stressors that can activate the HPA axis directly or via induced inflammation (e.g., through IL-6 and TNF- release), thereby amplifying the neuroendocrine response [266, 296, 297, 361,362,363,364,365,366,367, 373]