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& Bullmore, E

Insights Imaging 2 , 225234 (2011)

blocking one pathway pharmacologically often requires simultaneous inhibition of multiple molecular entities and cascades, thus hindering specificity

High concentrations and prolonged exposure to ROS causes extensive damage to various integral cellular biomolecules (Figure 1B), including proteins, lipids and nucleic acids, which ultimately hampers multiple cellular functions (49, 88)