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Multiple experimental models reported improved collagen organization, enhanced tensile strength, and pro-angiogenic signaling following injury

Systemic delivery via injection ensures adequate tissue concentrations while topical application provides direct contact with the scalp surface and upper follicle structures

Its short half-life, however, required it to be injected several times a day, which limited its appeal as a drug, and the company ran out of funding

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Supplementary Table S1 provided the main characteristics of included clinical trial and case-report studies which investigated the effect of nutrient supplements on migraine