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However, it has been reported that chicken DT40 cells lacking ADH5 can grow normally, and their sensitivity to exogenous formaldehyde is not different from wild-type cells [12]

Stress, environmental pollution, illness, inflammation, or an unbalanced diet can also increase the consumption of glutathione in cells

DUB activity can be affected by the existence of such chains as is for example well illustrated by the finding that the DUB MINDY-1 only processes tetraUb or longer Lys48-linked chains 67