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Capitalizing on the druggable nature of the ubiquitin system, significant progress has been made, particularly with proteolysis-targeting chimeras (PROTACs), which demonstrate compelling radiosensitizing effects [14, 15]

The absence of approval reflects the absence of a demonstrated favorable benefitrisk balance in the indications studied, not an untested promise waiting to be fulfilled

The authors also acknowledge the use of Grammarly (Grammarly Inc.) for proofreading and improving the clarity, readability, grammar, and overall language quality of the manuscript

Moreover, grafting fetal astrocytes bearing SOD1G93A to the spinal cord of healthy mice precipitated ALS-like pathology 244 , while transplanting healthy astrocytes slowed ALS progression in rats carrying mutant SOD1 G93A (ref

For comparison, we expressed and purified r E