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To determine a causal role between senescent cells and tauopathy, we administered intermittent (once every two weeks) senolytic therapy (D+Q) to tau transgenic mice between the ages of 2023 months old with already present tau pathology, neurodegeneration, inflammation and brain atrophy (35)

This counter-screen strategy facilitates the exclusion of S mutants that are locally misfolded or have an expression defect

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Ellerby LM, Ellerby HM, Park SM, Holleran AL, Murphy AN, Fiskum G et al

The slower gastric emptying observed in females prolongs the residence time of drugs in the stomach, potentially delaying absorption kinetics (e.g., metoprolol, theophylline, and verapamil) (Soldin and Mattison 2009