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A recent systematic review and meta-analysis demonstrated increased small intestinal and whole gut permeability in MAFLD patients, even if this was not confirmed in all individual studies (134, 140, 141)

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The increased fatty acid metabolism and oxidative phosphorylation detected by snRNA-seq in the CD oncogene hepatocytes is also consistent with the recent reports that connect -catenin mutated tumor with fatty acid oxidation ( 50 , 55 )