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If there is clinical improvement and if a reticulocyte response is observed, the same amount may be given on alternate days for seven doses, then every three to four days for another two to three weeks
The pathogenetic mechanisms underlying this syndrome include disruption of hunger/satiety centers (damage to arcuate, ventromedial, and paraventricular hypothalamic nuclei), leptin resistance despite elevated circulating leptin levels, autonomic dysregulation with reduced energy expenditure, hypothalamic-pituitary axis dysfunction, and local inflammatory processes [87, 88]
Piccoli L, Park Y-J, Tortorici MA, Czudnochowski N, Walls AC, Beltramello M, et al
Neurological Applications Both peptides have demonstrated some therapeutic potential in neurological applications, though this represents a less extensively studied area
