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Ferroptotic tubular cells release DAMPs (e.g., HMGB1) and lipid peroxidation products (e.g., 4-HNE), which activate pattern recognition receptors on macrophages and neutrophils, inducing the secretion of pro-inflammatory cytokines (e.g., IL-33 and MCP-1)

These disrupted cycles may resume when disease activity subsides or if the follicle manages to remain in the anagen phase for a prolonged duration (Fig

After 2 h of APAP injection, APAP_Leu group was gavaged with leucine (1.5% w/v, 10ml/kg) and APAP group was given an equivalent volume of PBS

Identifying compound efficacy targets in phenotypic drug discovery