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On the other hand, choline-deficient models induced severe hepatic inflammation, oxidative stress and accelerated fibrosis with great rapidity via the up-regulation of TGF-1/-SMA and collagen deposition, without fully recapitulating obesity-driven insulin resistance

Sep 1990;82(3):209-16

It is likely that induction of ferroptosis in disease will occur through the erosion of ferroptosis defences that are ineffectually restored by disrupted or fatigued metabolic pathways