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Standard Dosing Parameters Primary Application Dosing 1-2 mg daily 2-3 mg daily or 2 mg 2-3x per week 1-2 mg daily (injectable or topical) 2-5 mg daily under medical supervision Clinical studies used 0.3 mg/mL injections, while systemic wound healing in animal studies used approximately 1.1 mg/kg body weight (translating to ~75 mg total for humans in divided doses)

While nCOP and Hierarchical HotNet performed well across different datasets and showed more stability across various PPI networks, their performance was inferior to RL-GenRisk (Supplementary Fig

Mixing method: - Dissolve in the water phase or a small compatible aqueous premix before adding to the main batch

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The freezing point of water was chosen to be a second reference