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FIGURE 7 Despite the leaps and bounds in ferroptosis-based cancer treatment, it still faces several challenges, especially in terms of regulatory mechanisms and its potential application in clinical cancer therapy (Figure 7)

In breast cancer cells, the presence of Trimethylamine N-oxide (TMAO) can trigger GSDME-mediated pyroptosis (Wang H

anti-ssDNA, anti-single-stranded DNA

Symptoms include fatigue, muscle cramps, difficulty sleeping, and irritability

Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice