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The balance between immunological activation and suppression can be significantly influenced by these checkpoints

C1q/TNF-related protein 5 upregulates 12/15-LOX through STAT6 signaling to accelerate the development of atherosclerosis, while inhibition of 12/15-LOX reduces LDL oxidation and improves atherosclerosis

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No toxic or lethal dose was achieved across a remarkably wide range of doses from 0.006 mg/kg to 20 mg/kg

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