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[] Lecithin-cholesterol acyltransferase (LCAT), also a hepatokine, mediates the crosstalk between the liver and the bone in the pathogenesis of hepatic osteodystrophy (HOD, a metabolic bone disease in patients with chronic liver diseases, e.g., alcoholic liver disease, NAFLD and NASH, primary sclerosing cholangitis, primary biliary cirrhosis, viral hepatitis, viral cirrhosis, Wilson disease, and hemochromatosis)

USA 108 , 1154811553 (2011)

Performed by an ISO/IEC 17025:2017 accredited laboratory

After standardization, dimensionality reduction, and clustering, we identified 23 distinct cell clusters visualized by UMAP (Fig

While intermediate metabolites associated with TCA cycle (Tricarboxylic Acid Cycle) such as fumarate, succinate, and malate were not significantly different between the groups, we suggest a decrease in mitochondrial activity may result in lower ATP generation as reported in other inflammatory conditions (65, 66)