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The study addressed two questions: whether the fragment retained activity when delivered enterally rather than parenterally, and whether the effects observed in rodent models translated to human adipose tissue at the cellular level

Any stomach disorders, or conditions like pernicious anemia where Intrinsic Factor is lacking, can prevent B12 absorption, as can intestinal inflammation such as Crohns disease if a damaged terminal ileum cannot take up vitamin B12

Authors contributions CLM and TMA conceived the study

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Study 3 was a randomized, active-controlled study in which 40 patients (1 to 12 years of age: 10 patients, 12 to 17 years of age: 30 patients) received Injectafer 15 mg/kg to a maximum single dose of up to 750 mg (whichever was smaller) on Days 0 and 7 for a maximum total dose of 1500 mg