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This study was supported by grants from the Southern China International Cooperation Base for Early Intervention and Functional Rehabilitation of Neurological Diseases (2015B050501003), Guangdong Provincial Engineering Center For Major Neurological Disease Treatment, Guangdong Provincial Translational Medicine Innovation Platform for Diagnosis and Treatment of Major Neurological Disease, Guangdong Provincial Clinical Research Center for Neurological Diseases

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At day 6 after the first infusion, the semaglutide-treated and GLP-1MK-801-treated mice were crossed-over in terms of treatment and administered with another single infusion of either GLP-1MK-801 (0.22 nmol, 2 l) and semaglutide (0.22 nmol, 2 l), respectively, while vehicle-treated mice received vehicle treatment once again