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This type of defect is particularly challenging because the gap is too large for the body to bridge through normal healing processes alone

183 The recruitment of these proteins leads to the formation of the death-inducing signaling complex, which induces the internalization of the receptor, and apoptotic reactions ensure via either caspase- or mitochondrial-mediated cascades

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This reaction neutralizes the highly reactive superoxide radical, converting it into hydrogen peroxide, which can then be processed by other antioxidant enzymes like catalase and glutathione peroxidase

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